|Other Accession||NM_013179, NP_037311|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Orexin, Hypocretin, Hcrt, Orexin-A, Hypocretin-1, Hcrt1, Orexin-B, Hypocretin-2, Hcrt2, Hcrt, Ox, Ppox|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Hcrt antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Hcrt Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.|
|Cellular Location||Rough endoplasmic reticulum. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses|
|Tissue Location||Produced by a small group of neurons restricted to the lateral and posterior hypothalamus and perifornical areas. Positive neurons project widely throughout the entire neuroaxis. Particularly abundant projections in the cerebral cortex, olfactory bulb, hippocampus, amygdala, septum, diagonal band of Broca, bed nucleus of the stria terminalis, thalamus, anterior and posterior hypothalamus, midbrain, brainstem, and spinal cord. Immunoreactivity reported in the enteric nervous system and pancreas. In small amount, also detected in the testis|
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Provided below are standard protocols that you may find useful for product applications.
Sakurai T.,et al.Cell 92:573-585(1998).
de Lecea L.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:322-327(1998).
Hungs M.,et al.Bioessays 23:397-408(2001).
Willie J.T.,et al.Annu. Rev. Neurosci. 24:429-458(2001).
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