Rnls antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | A7RDN6 |
Other Accession | NM_001167818, NP_001161290 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Chicken, Guinea Pig |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 33kDa |
Alias Symbol | 6530404N21Rik, AI452315, AW060440, C10orf59 |
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Other Names | Renalase, 1.6.3.5, Monoamine oxidase-C, MAO-C, mMAO-C, alpha-NAD(P)H oxidase/anomerase, Rnls {ECO:0000312|MGI:MGI:1915045} |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Rnls antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Rnls antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Rnls {ECO:0000312|MGI:MGI:1915045} |
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Function | Catalyzes the oxidation of the less abundant 1,2-dihydro- beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. |
Cellular Location | Secreted. |
Tissue Location | Expressed predominantly in kidney and testis with lower levels in liver, heart and embryo and weak expression in brain and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
References
Wang J.,et al.Mol. Biol. Rep. 35:613-620(2008).
Carninci P.,et al.Science 309:1559-1563(2005).
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