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Opn3 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9WUK7 |
| Other Accession | NM_010098, NP_034228 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Chicken, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 45kDa |
| Gene ID | 13603 |
|---|---|
| Alias Symbol | ERO, Ecpn, MGC124138, panopsin |
| Other Names | Opsin-3, Encephalopsin, Panopsin, Opn3, Ecpn |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Opn3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Opn3 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Opn3 |
|---|---|
| Synonyms | Ecpn |
| Function | G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed:30284927). Binds both 11-cis retinal and all-trans retinal (By similarity). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (By similarity). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (By similarity). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (By similarity). Required for TYR and DCT blue light-induced complex formation in melanocytes (By similarity). Involved in keratinocyte differentiation in response to blue-light (By similarity). Required for the UVA- mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (By similarity). Plays a role in light- mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (PubMed:32040503). May be involved in photorelaxation of airway smooth muscle cells, via blue- light dependent GPCR signaling pathways (PubMed:30284927). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9H1Y3}; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q9H1Y3} |
| Tissue Location | Expressed in the eye (at protein level) (PubMed:30284927). Expressed in tracheal airway smooth muscle (PubMed:30284927). Expressed in brown adipocyte tissue; expression becomes more abundant during differentiation (PubMed:32040503) Strongly expressed in brain (PubMed:10234000). Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus (PubMed:10234000). Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord (PubMed:10234000) |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Blackshaw S.,et al.J. Neurosci. 19:3681-3690(1999).
Kasper G.,et al.Gene 295:27-32(2002).
Carninci P.,et al.Science 309:1559-1563(2005).
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$ 389.00
Cat# AI14464
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