|Other Accession||NM_011784, NP_035914|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Dog|
|Predicted||Human, Mouse, Rabbit|
|Alias Symbol||APJ, Agtrl1, msr/apj|
|Other Names||Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, MSR, Aplnr, Agtrl1, Apj|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Aplnr antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Aplnr antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Detected in the endothelium of the primary blood vessels and the forming heart. Might be expressed in a subpopulation of endothelial precursors and a mesenchymal population derived from paraaxial mesoderm|
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Devic E.,et al.Mech. Dev. 84:199-203(1999).
Carninci P.,et al.Science 309:1559-1563(2005).
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