|Reactivity||Human, Rat, Rabbit, Pig|
|Predicted||Human, Rabbit, Pig|
|Other Names||Dipeptidyl peptidase 1, 18.104.22.168, Cathepsin C, Cathepsin J, Dipeptidyl peptidase I, DPP-I, DPPI, Dipeptidyl transferase, Dipeptidyl peptidase 1 exclusion domain chain, Dipeptidyl peptidase I exclusion domain chain, Dipeptidyl peptidase 1 heavy chain, Dipeptidyl peptidase I heavy chain, Dipeptidyl peptidase 1 light chain, Dipeptidyl peptidase I light chain, CTSC, CPPI|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CTSC antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CTSC Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.|
|Tissue Location||Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Paris A.,et al.FEBS Lett. 369:326-330(1995).
Rao N.V.,et al.J. Biol. Chem. 272:10260-10265(1997).
Allende L.M.,et al.Hum. Mutat. 17:152-153(2001).
Allende L.M.,et al.Mol. Genet. Metab. 79:146-148(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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