CTSC Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P53634 |
Reactivity | Human, Rat, Rabbit, Pig |
Predicted | Human, Rabbit, Pig |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 50kDa |
Gene ID | 1075 |
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Other Names | Dipeptidyl peptidase 1, 3.4.14.1, Cathepsin C, Cathepsin J, Dipeptidyl peptidase I, DPP-I, DPPI, Dipeptidyl transferase, Dipeptidyl peptidase 1 exclusion domain chain, Dipeptidyl peptidase I exclusion domain chain, Dipeptidyl peptidase 1 heavy chain, Dipeptidyl peptidase I heavy chain, Dipeptidyl peptidase 1 light chain, Dipeptidyl peptidase I light chain, CTSC, CPPI |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CTSC antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | CTSC Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CTSC |
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Synonyms | CPPI |
Function | Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921). |
Cellular Location | Lysosome. |
Tissue Location | Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
References
Paris A.,et al.FEBS Lett. 369:326-330(1995).
Rao N.V.,et al.J. Biol. Chem. 272:10260-10265(1997).
Allende L.M.,et al.Hum. Mutat. 17:152-153(2001).
Allende L.M.,et al.Mol. Genet. Metab. 79:146-148(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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