|Other Accession||NM_032581, NP_115970|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Mouse, Rat, Bovine, Dog|
|Alias Symbol||DRCTNNB1A, HCC, HLD5, HYCC1|
|Other Names||Hyccin, Down-regulated by CTNNB1 protein A, Protein FAM126A, FAM126A, DRCTNNB1A|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-FAM126A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FAM126A antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway (Probable).|
|Cellular Location||Cytoplasm, cytosol. Cell membrane. Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex|
|Tissue Location||Widely expressed. Highest levels in heart, brain, placenta, spleen and testis.|
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Provided below are standard protocols that you may find useful for product applications.
Kawasoe T.,et al.Cancer Res. 60:3354-3358(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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