|Other Accession||NM_016586, NP_057670|
|Reactivity||Human, Rabbit, Horse, Bovine, Guinea Pig|
|Predicted||Human, Rabbit, Pig, Horse, Bovine, Guinea Pig|
|Other Names||MAP3K12-binding inhibitory protein 1, MAPK upstream kinase-binding inhibitory protein, MUK-binding inhibitory protein, MBIP|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-MBIP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MBIP Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shows a cytoplasmic localization when coexpressed with MAP3K12|
|Tissue Location||Ubiquitous. High expression seen in the heart and lung|
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Provided below are standard protocols that you may find useful for product applications.
Fukuyama K.,et al.J. Biol. Chem. 275:21247-21254(2000).
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
Li W.B.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
Daub H.,et al.Mol. Cell 31:438-448(2008).
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