|Other Accession||NM_194286, NP_919262|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||KIAA1853, MGC176729, MU-MB-2.76, nSR100|
|Other Names||Serine/arginine repetitive matrix protein 4, Medulloblastoma antigen MU-MB-2.76, Neural-specific serine/arginine repetitive splicing factor of 100 kDa, Neural-specific SR-related protein of 100 kDa, nSR100, SRRM4, KIAA1853|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SRRM4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SRRM4 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity).|
|Tissue Location||Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum|
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Nagase T.,et al.DNA Res. 8:85-95(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Behrends U.,et al.Int. J. Cancer 106:244-251(2003).
Calarco J.A.,et al.Cell 138:898-910(2009).
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