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SRRM4 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - SRRM4 antibody - middle region AI14514

    WB Suggested Anti-SRRM4 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:1562500
    Positive Control: Human Liver
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession A7MD48
Other Accession NM_194286, NP_919262
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rabbit, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 68kDa
Additional Information
Gene ID 84530
Alias Symbol KIAA1853, MGC176729, MU-MB-2.76, nSR100
Other Names Serine/arginine repetitive matrix protein 4, Medulloblastoma antigen MU-MB-2.76, Neural-specific serine/arginine repetitive splicing factor of 100 kDa, Neural-specific SR-related protein of 100 kDa, nSR100, SRRM4, KIAA1853
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-SRRM4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSRRM4 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SRRM4
Synonyms KIAA1853
Function Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural- specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:30684677). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q8BKA3}.
Tissue Location Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum
Research Areas
Citations (0)
citation

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References

Nagase T.,et al.DNA Res. 8:85-95(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Behrends U.,et al.Int. J. Cancer 106:244-251(2003).
Calarco J.A.,et al.Cell 138:898-910(2009).

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$ 389.00
Cat# AI14514
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