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Wibg Antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - Wibg Antibody - middle region AI14527

    Host: Rabbit
    Target Name: Wibg
    Sample Tissue: Mouse Thymus lysates
    Antibody Dilution: 1.0μg/ml
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q8CHP5
Other Accession NM_001170869, NP_001164340
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 22kDa
Additional Information
Gene ID 78428
Alias Symbol A030010B05Rik, Pym
Other Names Partner of Y14 and mago, Protein wibg homolog, Wibg, Pym
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Wibg antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsWibg Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pym1 {ECO:0000312|MGI:MGI:1925678}
Synonyms Pym, Wibg
Function Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon- exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9BRP8}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9BRP8}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9BRP8}. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1 {ECO:0000250|UniProtKB:Q9BRP8}
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$ 389.00
Cat# AI14527
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