|Other Accession||NM_032811, NP_116200|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Alias Symbol||FLJ14621, FLJ25020, FLJ90113, MGC129890, NIAM, TB-5|
|Other Names||Transforming growth factor beta regulator 1, Nuclear interactor of ARF and Mdm2, TBRG1, NIAM|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TBRG1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TBRG1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.|
|Tissue Location||Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma|
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Provided below are standard protocols that you may find useful for product applications.
Tompkins V.S.,et al.J. Biol. Chem. 282:1322-1333(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zhou G.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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