|Other Accession||NM_017781, NP_060251|
|Reactivity||Human, Rat, Pig, Horse, Bovine, Dog|
|Predicted||Human, Pig, Bovine, Dog|
|Other Names||Cytochrome P450 2W1, 1.14.14.-, CYPIIW1, CYP2W1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CYP2W1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CYP2W1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).|
|Cellular Location||Endoplasmic reticulum lumen. Cell membrane. Note=About 8% are expressed on the cell surface.|
|Tissue Location||Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors|
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Provided below are standard protocols that you may find useful for product applications.
Hillier L.W.,et al.Nature 424:157-164(2003).
Karlgren M.,et al.Biochem. Biophys. Res. Commun. 341:451-458(2006).
Wu Z.L.,et al.Mol. Pharmacol. 69:2007-2014(2006).
Gomez A.,et al.Mol. Pharmacol. 78:1004-1011(2010).
Eun C.Y.,et al.Toxicol. Res. 26:171-175(2010).
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