|Other Accession||NM_133492, NP_597999|
|Alias Symbol||ASAH3, MGC138327, MGC138329, ALKCDase1|
|Other Names||Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, 22.214.171.124, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, ACER1, ASAH3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ACER1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ACER1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Mainly expressed in epidermis.|
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Provided below are standard protocols that you may find useful for product applications.
Mao C.,et al.J. Biol. Chem. 278:31184-31191(2003).
Houben E.,et al.J. Lipid Res. 47:1063-1070(2006).
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