|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Cytochrome P450 4F8, 188.8.131.52, CYPIVF8, CYP4F8|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-CP4F8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CP4F8 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydroxylates arachidonic acid (20:4n-6) to (18R)- hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3- hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein Microsome membrane|
|Tissue Location||Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions|
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Provided below are standard protocols that you may find useful for product applications.
Bylund J.,et al.Biochem. Biophys. Res. Commun. 261:169-174(1999).
Bylund J.,et al.J. Biol. Chem. 275:21844-21849(2000).
Stark K.,et al.Arch. Biochem. Biophys. 409:188-196(2003).
Stark K.,et al.Arch. Biochem. Biophys. 441:174-181(2005).
Stark K.,et al.Prostaglandins Other Lipid Mediat. 75:47-64(2005).
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