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Casp3 Antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Casp3 Antibody - middle region AI14598

    Host: Rabbit
    Target Name: Casp3
    Sample Tissue: Mouse Liver lysates
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P70677
Other Accession NM_009810, NP_033940
Reactivity Human, Rat, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Rat, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 31kDa
Additional Information
Gene ID 12367
Alias Symbol A830040C14Rik, AC-3, Apopain, CC3, CPP32, Caspase-3, Lice, Yama, mldy
Other Names Caspase-3, CASP-3,, Apopain, Cysteine protease CPP32, CPP-32, LICE, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, Casp3, Cpp32
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Casp3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCasp3 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casp3
Synonyms Cpp32
Function Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Cellular Location Cytoplasm.
Tissue Location Highest expression in spleen, lung, liver, kidney and heart. Lower expression in brain, skeletal muscle and testis
Research Areas
Citations (0)

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Juan T.S.-C.,et al.Oncogene 13:749-755(1996).
Mukasa T.,et al.Biochem. Biophys. Res. Commun. 231:770-774(1997).
van de Craen M.,et al.FEBS Lett. 403:61-69(1997).
Fernandes-Alnemri T.,et al.Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
Denis F.,et al.Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.

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$ 293.00
Cat# AI14598
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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