|Other Accession||NM_009810, NP_033940|
|Reactivity||Human, Rat, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rat, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||A830040C14Rik, AC-3, Apopain, CC3, CPP32, Caspase-3, Lice, Yama, mldy|
|Other Names||Caspase-3, CASP-3, 22.214.171.124, Apopain, Cysteine protease CPP32, CPP-32, LICE, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, Casp3, Cpp32|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Casp3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Casp3 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.|
|Tissue Location||Highest expression in spleen, lung, liver, kidney and heart. Lower expression in brain, skeletal muscle and testis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Juan T.S.-C.,et al.Oncogene 13:749-755(1996).
Mukasa T.,et al.Biochem. Biophys. Res. Commun. 231:770-774(1997).
van de Craen M.,et al.FEBS Lett. 403:61-69(1997).
Fernandes-Alnemri T.,et al.Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
Denis F.,et al.Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.