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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   INPP5D antibody - C-terminal region   

INPP5D antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - INPP5D antibody - C-terminal region AI14603

    WB Suggested Anti-INPP5D Antibody Titration: 1.0 μg/ml
    Positive Control: THP-1 Whole Cell
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92835
Other Accession NM_001017915, NP_001017915
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 131kDa
Additional Information
Gene ID 3635
Alias Symbol MGC104855, MGC142140, MGC142142, SHIP, SHIP1, SIP-145, hp51CN
Other Names Phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase 1,, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D, SHIP, SHIP1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-INPP5D antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsINPP5D antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SHIP, SHIP1
Function Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate in membrane localization (By similarity)
Tissue Location Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level)
Research Areas
Citations (0)

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Drayer A.L.,et al.Biochem. Biophys. Res. Commun. 225:243-249(1996).
Ware M.D.,et al.Blood 88:2833-2840(1996).
Kavanaugh W.M.,et al.Curr. Biol. 6:438-445(1996).
Geier S.J.,et al.Blood 89:1876-1885(1997).
Odai H.,et al.Blood 89:2745-2756(1997).

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$ 293.00
Cat# AI14603
(40 western blots)
Availability: 2-3 days
Bulk Size
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