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ANPEP antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - ANPEP antibody - N-terminal region AI14607

    WB Suggested Anti-ANPEP Antibody Titration: 1.0 μg/ml
    Positive Control: Jurkat Whole Cell
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P15144
Other Accession NM_001150, NP_001141
Reactivity Human, Rat, Rabbit, Horse, Guinea Pig, Dog
Predicted Human, Horse, Guinea Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 106kDa
Additional Information
Gene ID 290
Alias Symbol APN, CD13, GP150, LAP1, P150, PEPN
Other Names Aminopeptidase N, AP-N, hAPN, 3.4.11.2, Alanyl aminopeptidase, Aminopeptidase M, AP-M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD13, ANPEP, APN, CD13, PEPN
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ANPEP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsANPEP antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANPEP
Synonyms APN, CD13, PEPN
Function Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
Cellular Location Cell membrane; Single-pass type II membrane protein. Note=Also found as a soluble form
Tissue Location Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
Research Areas
Citations (0)
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References

Olsen J.,et al.FEBS Lett. 238:307-314(1988).
Look A.T.,et al.J. Clin. Invest. 83:1299-1307(1989).
Zody M.C.,et al.Nature 440:671-675(2006).
Shapiro L.H.,et al.J. Biol. Chem. 266:11999-12007(1991).
Eiz-Vesper B.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.

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$ 389.00
Cat# AI14607
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