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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   ANPEP antibody - N-terminal region   

ANPEP antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - ANPEP antibody - N-terminal region AI14607

    WB Suggested Anti-ANPEP Antibody Titration: 1.0 μg/ml
    Positive Control: Jurkat Whole Cell
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15144
Other Accession NM_001150, NP_001141
Reactivity Human, Rat, Rabbit, Horse, Guinea Pig, Dog
Predicted Human, Horse, Guinea Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 106kDa
Additional Information
Gene ID 290
Alias Symbol APN, CD13, GP150, LAP1, P150, PEPN
Other Names Aminopeptidase N, AP-N, hAPN,, Alanyl aminopeptidase, Aminopeptidase M, AP-M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD13, ANPEP, APN, CD13, PEPN
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ANPEP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsANPEP antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms APN, CD13, PEPN
Function Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Cellular Location Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol. Note=A soluble form has also been detected
Tissue Location Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood- brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients
Research Areas
Citations (0)

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Olsen J.,et al.FEBS Lett. 238:307-314(1988).
Look A.T.,et al.J. Clin. Invest. 83:1299-1307(1989).
Zody M.C.,et al.Nature 440:671-675(2006).
Shapiro L.H.,et al.J. Biol. Chem. 266:11999-12007(1991).
Eiz-Vesper B.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.

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$ 293.00
Cat# AI14607
(40 western blots)
Availability: 2-3 days
Bulk Size
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