|Other Accession||NM_016829, NP_058438|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Horse, Bovine, Dog|
|Alias Symbol||HMMH, HOGG1, MUTM, OGH1|
|Other Names||N-glycosylase/DNA lyase, 8-oxoguanine DNA glycosylase, 3.2.2.-, DNA-(apurinic or apyrimidinic site) lyase, AP lyase, 184.108.40.206, OGG1, MMH, MUTM, OGH1|
|Target/Specificity||Directed against isoforms 2D, 1A, 1B, 2E.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-OGG1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||OGG1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MMH, MUTM, OGH1|
|Function||DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells Isoform 2A: Mitochondrion.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Aburatani H.,et al.Cancer Res. 57:2151-2156(1997).
Rosenquist T.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:7429-7434(1997).
Roldan-Arjona T.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8016-8020(1997).
Radicella J.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8010-8015(1997).
Lu R.,et al.Curr. Biol. 7:397-407(1997).
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