|Other Accession||NM_016829, NP_058438|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Horse, Bovine, Dog|
|Alias Symbol||HMMH, HOGG1, MUTM, OGH1|
|Other Names||N-glycosylase/DNA lyase, 8-oxoguanine DNA glycosylase, 3.2.2.-, DNA-(apurinic or apyrimidinic site) lyase, AP lyase, 220.127.116.11, OGG1, MMH, MUTM, OGH1|
|Target/Specificity||Directed against isoforms 2D, 1A, 1B, 2E.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-OGG1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||OGG1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MMH, MUTM, OGH1|
|Function||DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells Isoform 2A: Mitochondrion.|
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Provided below are standard protocols that you may find useful for product applications.
Aburatani H.,et al.Cancer Res. 57:2151-2156(1997).
Rosenquist T.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:7429-7434(1997).
Roldan-Arjona T.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8016-8020(1997).
Radicella J.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8010-8015(1997).
Lu R.,et al.Curr. Biol. 7:397-407(1997).
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