|Other Accession||NM_010480, NP_034610|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Dog|
|Alias Symbol||86kDa, 89kDa, AL024080, AL024147, Hsp86-1, Hsp89, Hsp90, Hspca, hsp4|
|Other Names||Heat shock protein HSP 90-alpha, Heat shock 86 kDa, HSP 86, HSP86, Tumor-specific transplantation 86 kDa antigen, TSTA, Hsp90aa1, Hsp86, Hsp86-1, Hspca|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Hsp90aa1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Hsp90aa1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Hsp86, Hsp86-1, Hspca|
|Function||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion (By similarity).|
|Cellular Location||Cytoplasm. Melanosome. Cell membrane|
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Provided below are standard protocols that you may find useful for product applications.
Moore S.K.,et al.J. Biol. Chem. 264:5343-5351(1989).
Moore S.K.,et al.Genomics 10:1019-1029(1991).
Ullrich S.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:3121-3125(1986).
Minami Y.,et al.Mol. Cell. Biol. 14:1459-1464(1994).
Hoffmann T.,et al.Gene 74:491-501(1988).
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