|Other Accession||NM_010480, NP_034610|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Dog|
|Alias Symbol||86kDa, 89kDa, AL024080, AL024147, Hsp86-1, Hsp89, Hsp90, Hspca, hsp4|
|Other Names||Heat shock protein HSP 90-alpha, Heat shock 86 kDa, HSP 86, HSP86, Tumor-specific transplantation 86 kDa antigen, TSTA, Hsp90aa1, Hsp86, Hsp86-1, Hspca|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Hsp90aa1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Hsp90aa1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Hsp86, Hsp86-1, Hspca|
|Function||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.|
|Cellular Location||Cytoplasm. Melanosome. Cell membrane|
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Provided below are standard protocols that you may find useful for product applications.
Moore S.K.,et al.J. Biol. Chem. 264:5343-5351(1989).
Moore S.K.,et al.Genomics 10:1019-1029(1991).
Ullrich S.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:3121-3125(1986).
Minami Y.,et al.Mol. Cell. Biol. 14:1459-1464(1994).
Hoffmann T.,et al.Gene 74:491-501(1988).
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