|Other Accession||NM_004513, NP_004504|
|Reactivity||Human, Pig, Goat, Horse|
|Predicted||Human, Pig, Goat, Horse|
|Alias Symbol||FLJ16806, FLJ42735, FLJ44234, LCF, NIL16, PRIL16, prIL-16|
|Other Names||Pro-interleukin-16, Interleukin-16, IL-16, Lymphocyte chemoattractant factor, LCF, IL16|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-IL16 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||IL16 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.|
|Cellular Location||Interleukin-16: Secreted. Isoform 3: Cytoplasm. Nucleus.|
|Tissue Location||Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation|
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Provided below are standard protocols that you may find useful for product applications.
Bannert N.,et al.J. Biol. Chem. 278:42190-42199(2003).
Wang P.,et al.BMC Genomics 10:518-518(2009).
Kornfeld H.,et al.Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
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