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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CAMK4 antibody - N-terminal region   

CAMK4 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - CAMK4 antibody - N-terminal region AI14659

    WB Suggested Anti-CAMK4 Antibody Titration: 1.0 μg/ml
    Positive Control: ACHN Whole Cell
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16566
Other Accession NM_001744, NP_001735
Reactivity Human, Mouse, Rat, Horse, Dog
Predicted Human, Mouse, Rat, Pig, Chicken, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 52kDa
Additional Information
Gene ID 814
Alias Symbol CaMK-GR, MGC36771, IV, caMK, CaMK IV
Other Names Calcium/calmodulin-dependent protein kinase type IV, CaMK IV,, CaM kinase-GR, CAMK4, CAMK, CAMK-GR, CAMKIV
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CAMK4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCAMK4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAMK4
Function Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Cellular Location Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity).
Tissue Location Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue
Research Areas
Citations (0)

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Kitani T.,et al.J. Biochem. 115:637-640(1994).
Bland M.M.,et al.Gene 142:191-197(1994).
Mosialos G.,et al.J. Virol. 68:1697-1705(1994).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Hanissian S.H.,et al.J. Biol. Chem. 268:20055-20063(1993).

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$ 293.00
Cat# AI14659
(40 western blots)
Availability: 2-3 days
Bulk Size
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