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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   EIF6 antibody - N-terminal region   

EIF6 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - EIF6 antibody - N-terminal region AI14664

    WB Suggested Anti-EIF6 Antibody Titration: 1.0 μg/ml
    Positive Control: Hela Whole CellEIF6 is supported by BioGPS gene expression data to be expressed in HeLa
  • WB - EIF6 antibody - N-terminal region AI14664

    Host:Rabbit
    Target Name:EIF6
    Sample Tissue:Human 721_B
    Antibody Dilution: 1.0μg/mlEIF6 is supported by BioGPS gene expression data to be expressed in 721_B
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P56537
Other Accession NM_002212, NP_002203
Reactivity Human, Mouse, Rat, Rabbit, Sheep, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Chicken, Sheep, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 27kDa
Additional Information
Gene ID 3692
Alias Symbol 2, CAB, EIF3A, ITGB4BP, b, b(2)gcn, gcn, p27BBP, eIF-6, p27(BBP)
Other Names Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132}, eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132}, B(2)GCN homolog, B4 integrin interactor, CAB, p27(BBP), EIF6 {ECO:0000255|HAMAP-Rule:MF_03132}
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-EIF6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsEIF6 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IF6
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS- dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA- induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).
Cellular Location Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus
Tissue Location Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level)
Research Areas
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References

Si K.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:14285-14290(1997).
Biffo S.,et al.J. Biol. Chem. 272:30314-30321(1997).
Donadini A.,et al.Gene 266:35-43(2001).
Mao M.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 293.00
Cat# AI14664
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