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Git1 Antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Git1 Antibody - middle region AI14674

    Host: Rabbit
    Target Name: Git1
    Sample Tissue: Rat Pancreas lysates
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Z272
Other Accession NM_031814, NP_114002
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 84kDa
Additional Information
Gene ID 83709
Other Names ARF GTPase-activating protein GIT1, ARF GAP GIT1, Cool-associated and tyrosine-phosphorylated protein 1, CAT-1, CAT1, G protein-coupled receptor kinase-interactor 1, GRK-interacting protein 1, Git1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Git1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsGit1 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Git1
Function GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity).
Cellular Location Cytoplasm. Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions Recruitment to adhesions may be mediated by active tyrosine- phosphorylated paxillin (By similarity).
Tissue Location Expressed in numerous tissues, with highest levels in testis.
Citations (0)

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Premont R.T.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:14082-14087(1998).
Zhao Z.-S.,et al.Mol. Cell. Biol. 20:6354-6363(2000).
Nishiya N.,et al.J. Biochem. 132:279-289(2002).
Ko J.,et al.J. Neurosci. 23:1667-1677(2003).

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$ 293.00
Cat# AI14674
(40 western blots)
Availability: 2-3 days
Bulk Size
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