|Other Accession||NM_014646, NP_055461|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Phosphatidate phosphatase LPIN2, 22.214.171.124, Lipin-2, LPIN2, KIAA0249|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-LPIN2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||LPIN2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity).|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate.|
|Tissue Location||Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.|
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Provided below are standard protocols that you may find useful for product applications.
Nagase T.,et al.DNA Res. 3:321-329(1996).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Olsen J.V.,et al.Cell 127:635-648(2006).
Donkor J.,et al.J. Biol. Chem. 282:3450-3457(2007).
Zahedi R.P.,et al.J. Proteome Res. 7:526-534(2008).
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