|Other Accession||NM_004332, NP_004323|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rabbit, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||BPH-RP, MCNAA, MGC125930, MGC41865, VACVASE|
|Other Names||Valacyclovir hydrolase, VACVase, Valacyclovirase, 3.1.-.-, Biphenyl hydrolase-like protein, Biphenyl hydrolase-related protein, Bph-rp, Breast epithelial mucin-associated antigen, MCNAA, BPHL, MCNAA|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-BPHL antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||BPHL antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.|
|Tissue Location||Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Puente X.S.,et al.J. Biol. Chem. 270:12926-12932(1995).
Puente X.S.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Larocca D.,et al.Cancer Res. 50:5925-5930(1990).
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