|Other Accession||NM_001249, NP_001240|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||CD39L4, MGC163357, MGC163359, NTPDase-5, PCPH|
|Other Names||Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, 18.104.22.168, CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, 22.214.171.124, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, UDPase ENTPD5, ENTPD5, CD39L4, PCPH|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ENTPD5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ENTPD5 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.|
|Cellular Location||Endoplasmic reticulum. Secreted|
|Tissue Location||Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Chadwick B.P.,et al.Genomics 50:357-367(1998).
Recio J.A.,et al.Mol. Carcinog. 27:229-236(2000).
Murphy-Piedmonte D.M.,et al.Biochim. Biophys. Acta 1747:251-259(2005).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.