|Other Accession||NM_028733, NP_083009|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||4921507A02Rik, 6330413E15Rik, AW413130|
|Other Names||Protein kinase C and casein kinase II substrate protein 3, Pacsin3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Pacsin3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Pacsin3 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the inner aspect of the plasma membrane in myotubes|
|Tissue Location||Highly expressed in skeletal muscle, heart and lung; also detected in brain, kidney and uterus (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Modregger J.,et al.J. Cell Sci. 113:4511-4521(2000).
Sumoy L.,et al.Gene 262:199-205(2001).
Cuajungco M.P.,et al.J. Biol. Chem. 281:18753-18762(2006).
Roach W.,et al.Biochem. Biophys. Res. Commun. 355:745-750(2007).
Villen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
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