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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CHMP2A antibody - N-terminal region   

CHMP2A antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - CHMP2A antibody - N-terminal region AI14775

    WB Suggested Anti-CHMP2A Antibody Titration: 1.0 μg/ml
    Positive Control: Fetal Lung
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43633
Other Accession NM_014453, NP_055268
Reactivity Human, Mouse, Rat, Rabbit, Goat, Bovine, Guinea Pig, Dog
Predicted Rat, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Additional Information
Gene ID 27243
Alias Symbol BC-2, BC2, CHMP2, VPS2, VPS2A
Other Names Charged multivesicular body protein 2a, Chromatin-modifying protein 2a, CHMP2a, Putative breast adenocarcinoma marker BC-2, Vacuolar protein sorting-associated protein 2-1, Vps2-1, hVps2-1, CHMP2A, BC2, CHMP2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CHMP2A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCHMP2A antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BC2, CHMP2
Function Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV- 1 p6- and p9-dependent virus release.
Cellular Location Late endosome membrane; Peripheral membrane protein; Cytoplasmic side Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body
Research Areas
Citations (0)

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Slater C.,et al.Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Koczan D.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Kemmer D.,et al.BMC Genomics 7:48-48(2006).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 293.00
Cat# AI14775
(40 western blots)
Availability: 2-3 days
Bulk Size
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