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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   CLEC5A antibody - C-terminal region   

CLEC5A antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - CLEC5A antibody - C-terminal region AI14777

    WB Suggested Anti-CLEC5A Antibody Titration: 1.0 μg/ml
    Positive Control: THP-1 Whole Cell
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NY25
Other Accession NM_013252, NP_037384
Reactivity Human, Rat, Pig, Horse, Yeast, Bovine, Dog
Predicted Human, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 21kDa
Additional Information
Gene ID 23601
Alias Symbol CLECSF5, MDL-1, MDL1, MGC138304
Other Names C-type lectin domain family 5 member A, C-type lectin superfamily member 5, Myeloid DAP12-associating lectin 1, MDL-1, CLEC5A, CLECSF5, MDL1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CLEC5A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCLEC5A antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CLECSF5, MDL1
Function Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells
Research Areas
Citations (0)

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Bakker A.B.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:9792-9796(1999).
Mueller A.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
Chen S.T.,et al.Nature 453:672-676(2008).
Watson A.A.,et al.J. Biol. Chem. 286:24208-24218(2011).

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$ 293.00
Cat# AI14777
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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