|Other Accession||NM_014234, NP_055049|
|Alias Symbol||D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9|
|Other Names||Estradiol 17-beta-dehydrogenase 8, 126.96.36.199, 17-beta-hydroxysteroid dehydrogenase 8, 17-beta-HSD 8, 3-oxoacyl-[acyl-carrier-protein] reductase, 1.1.1.-, Protein Ke6, Ke-6, Really interesting new gene 2 protein, Testosterone 17-beta-dehydrogenase 8, 188.8.131.52, HSD17B8, FABGL, HKE6, RING2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-HSD17B8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HSD17B8 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FABGL, HKE6, RING2, SDR30C1|
|Function||NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508).|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ando A.,et al.Genomics 35:600-602(1996).
Ohno S.,et al.Mol. Cell. Biochem. 309:209-215(2008).
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