|Other Accession||NM_001195023, NP_001181952|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||AK129375, Npl4, mKIAA1499|
|Other Names||Nuclear protein localization protein 4 homolog, Protein NPL4, Nploc4, Kiaa1499, Npl4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Nploc4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Nploc4 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus Note=Associated with the endoplasmic reticulum and nuclear|
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Okazaki N.,et al.DNA Res. 10:167-180(2003).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Park J.,et al.Mol. Cell 50:919-930(2013).
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