|Other Accession||NM_052850, NP_443082|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rabbit, Guinea Pig, Dog|
|Alias Symbol||CKBBP2, CRIF1, MGC4667, MGC4758, PLINP-1, PRG6, Plinp1|
|Other Names||Growth arrest and DNA damage-inducible proteins-interacting protein 1, 39S ribosomal protein L59, mitochondrial, MRP-L59, CKII beta-associating protein, CR6-interacting factor 1, CRIF1, Papillomavirus L2-interacting nuclear protein 1, PLINP, PLINP-1, p53-responsive gene 6 protein, GADD45GIP1, MRPL59, PLINP1, PRG6|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-GADD45GIP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GADD45GIP1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MRPL59, PLINP1, PRG6|
|Function||Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.|
|Cellular Location||Mitochondrion. Nucleus. Note=Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C- terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275).|
|Tissue Location||Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer|
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Provided below are standard protocols that you may find useful for product applications.
Goernemann J.,et al.Virology 303:69-78(2002).
Chung H.K.,et al.J. Biol. Chem. 278:28079-28088(2003).
Frigimelica E.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Horikoshi N.,et al.Biochem. Biophys. Res. Commun. 261:864-869(1999).
Park K.C.,et al.Mol. Endocrinol. 19:12-24(2005).
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