|Alias Symbol||PPP6C, PPP6,|
|Other Names||Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, 22.214.171.124, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C, PPP6|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-PPP6C antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PPP6C Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.|
|Tissue Location||Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
Bastians H.,et al.J. Cell Sci. 109:2865-2874(1996).
Filali M.,et al.J. Cell. Biochem. 73:153-163(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
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