|Other Accession||NM_020967, NP_066018|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||CIA, bA465L10.6|
|Other Names||Nuclear receptor coactivator 5, NCoA-5, Coactivator independent of AF-2, CIA, NCOA5, KIAA1637|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-NCOA5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NCOA5 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Sauve F.,et al.Mol. Cell. Biol. 21:343-353(2001).
Jiang C.,et al.J. Biol. Chem. 279:27781-27789(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 7:273-281(2000).
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