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>   home   >   Products   >   Primary Antibodies   >   Ell3 Antibody - C-terminal region   

Ell3 Antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - Ell3 Antibody - C-terminal region AI14848

    Host: Rabbit
    Target Name: Ell3
    Sample Tissue: Mouse Kidney lysates
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q80VR2
Other Accession NM_145973, NP_666085
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 45kDa
Additional Information
Gene ID 269344
Alias Symbol A930015D22Rik
Other Names RNA polymerase II elongation factor ELL3, Ell3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Ell3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsEll3 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ell3
Function Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P- TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT).
Cellular Location Nucleus.
Tissue Location Actively expressed in embryonic stem cells (ES cells), while it is weakly expressed in differentiated cells
Citations (0)

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Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Lin C.,et al.Mol. Cell 37:429-437(2010).
Ahn H.J.,et al.PLoS ONE 7:E40293-E40293(2012).
Lin C.,et al.Cell 152:144-156(2013).

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$ 293.00
Cat# AI14848
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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