|Other Accession||NM_181716, NP_859067|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Alias Symbol||3110013H01Rik, CENP-V, PRR6, p30|
|Other Names||Centromere protein V, CENP-V, Nuclear protein p30, Proline-rich protein 6, CENPV, PRR6|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CENPV antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CENPV antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.|
|Cellular Location||Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Enriched at the nuclear periphery and around the nucleolus (PubMed:12196509). In mitotic cells, localizes to kinetochores from prometaphase to metaphase (PubMed:18772885). At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis (PubMed:18772885)|
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Provided below are standard protocols that you may find useful for product applications.
Zheng H.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Cronshaw J.M.,et al.J. Cell Biol. 158:915-927(2002).
Tadeu A.M.B.,et al.EMBO J. 27:2510-2522(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
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