|Other Accession||NM_003094, NP_003085|
|Reactivity||Human, Mouse, Rat, Bovine, Guinea Pig, Dog|
|Predicted||Mouse, Rat, Dog|
|Alias Symbol||B-raf, SME, Sm-E|
|Other Names||Small nuclear ribonucleoprotein E, snRNP-E, Sm protein E, Sm-E, SmE, SNRPE|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SNRPE antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SNRPE antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=SMN- mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes|
|Tissue Location||Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis|
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Provided below are standard protocols that you may find useful for product applications.
Stanford D.R.,et al.Nucleic Acids Res. 16:10593-10605(1988).
Stanford D.R.,et al.J. Biol. Chem. 263:17772-17779(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Stanford D.R.,et al.J. Biol. Chem. 262:9931-9934(1987).
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