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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   UCP1 antibody - N-terminal region   

UCP1 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - UCP1 antibody - N-terminal region AI14934

    WB Suggested Anti-UCP1 Antibody Titration: 1.0 μg/ml
    Positive Control: Jurkat Whole Cell
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P25874
Other Accession NM_021833, NP_068605
Reactivity Human, Rabbit
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 34kDa
Additional Information
Gene ID 7350
Alias Symbol SLC25A7, UCP
Other Names Mitochondrial brown fat uncoupling protein 1, UCP 1, Solute carrier family 25 member 7, Thermogenin, UCP1, SLC25A7, UCP
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-UCP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsUCP1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UCP1 (HGNC:12517)
Function Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).
Cellular Location Mitochondrion inner membrane {ECO:0000250|UniProtKB:P12242}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04633}
Tissue Location Brown adipose tissue.
Research Areas
Citations (0)

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References

Cassard A.M.,et al.J. Cell. Biochem. 43:255-264(1990).
Bouillaud F.,et al.Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
Bouillaud F.,et al.Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Bouillaud F.,et al.Clin. Sci. 75:21-27(1988).

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$ 293.00
Cat# AI14934
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