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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CLPX antibody - C-terminal region   

CLPX antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - CLPX antibody - C-terminal region AI14959

    WB Suggested Anti-CLPX Antibody Titration: 1.0 μg/ml
    Positive Control: 293T Whole CellCLPX is supported by BioGPS gene expression data to be expressed in HEK293T
  • WB - CLPX antibody - C-terminal region AI14959

    Host: Rabbit
    Target Name: NOP56
    Sample Tissue: MCF7
    Antibody Dilution: 1.0μg/mlCLPX is supported by BioGPS gene expression data to be expressed in MCF7
  • WB - CLPX antibody - C-terminal region AI14959

    Host: Rabbit
    Target Name: WT1
    Sample Tissue: 721_B
    Antibody Dilution: 1.0μg/mlCLPX is supported by BioGPS gene expression data to be expressed in 721_B
  • WB - CLPX antibody - C-terminal region AI14959

    Host: Rabbit
    Target Name: EGFL8
    Sample Tissue: Hela
    Antibody Dilution: 1.0μg/mlCLPX is supported by BioGPS gene expression data to be expressed in HeLa
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O76031
Other Accession NM_006660, NP_006651
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 70kDa
Additional Information
Gene ID 10845
Other Names ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial, CLPX
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CLPX antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCLPX antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLPX
Function ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP- dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689).
Cellular Location Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid
Tissue Location Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.
Research Areas
Citations (0)

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References

Corydon T.J.,et al.Mamm. Genome 11:899-905(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kang S.G.,et al.J. Biol. Chem. 277:21095-21102(2002).
Kang S.G.,et al.J. Struct. Biol. 148:338-352(2004).

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$ 293.00
Cat# AI14959
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