|Other Accession||NM_006660, NP_006651|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Dog|
|Other Names||ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial, CLPX|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CLPX antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CLPX antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure.|
|Cellular Location||Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid|
|Tissue Location||Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Corydon T.J.,et al.Mamm. Genome 11:899-905(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kang S.G.,et al.J. Biol. Chem. 277:21095-21102(2002).
Kang S.G.,et al.J. Struct. Biol. 148:338-352(2004).
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