|Other Accession||NM_001002273, NP_001002273|
|Alias Symbol||CD32, CD32B, FCG2, FCGR2, IGFR2|
|Other Names||Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD32, FCGR2B, CD32, FCG2, IGFR2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-FCGR2B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FCGR2B antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD32, FCG2, IGFR2|
|Function||Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells|
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Provided below are standard protocols that you may find useful for product applications.
Ng S.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Stuart S.G.,et al.EMBO J. 8:3657-3666(1989).
Brooks D.G.,et al.J. Exp. Med. 170:1369-1385(1989).
Engelhardt W.,et al.Eur. J. Immunol. 20:1367-1377(1990).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
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