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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CAMK1 antibody - N-terminal region   

CAMK1 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - CAMK1 antibody - N-terminal region AI15023

    WB Suggested Anti-CAMK1 Antibody Titration: 1.0 μg/ml
    Positive Control: A549 Whole CellCAMK1 is supported by BioGPS gene expression data to be expressed in A549
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14012
Other Accession NM_003656, NP_003647
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 41kDa
Additional Information
Gene ID 8536
Alias Symbol CAMKI, MGC120317, MGC120318
Other Names Calcium/calmodulin-dependent protein kinase type 1,, CaM kinase I, CaM-KI, CaM kinase I alpha, CaMKI-alpha, CAMK1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CAMK1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCAMK1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAMK1
Function Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser- 498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen- stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Tissue Location Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex
Research Areas
Citations (0)

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Haribabu B.,et al.EMBO J. 14:3679-3686(1995).
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
Hsu L.-S.,et al.J. Biomed. Sci. 5:141-149(1998).
McKinsey T.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:14400-14405(2000).
Hsu L.-S.,et al.J. Biol. Chem. 276:31113-31123(2001).

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$ 293.00
Cat# AI15023
(40 western blots)
Availability: 2-3 days
Bulk Size
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