|Other Accession||NM_005346, NP_005337|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||FLJ54328, HSP70-1B, HSP70-2, HSPA1A|
|Other Names||Heat shock 70 kDa protein 1A/1B, Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP70.1/HSP70.2, HSPA1A, HSPA1, HSX70|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-HSPA1B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HSPA1B antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).|
|Cellular Location||Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs|
|Tissue Location||HSPA1B is testis-specific.|
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Provided below are standard protocols that you may find useful for product applications.
Milner C.M.,et al.Immunogenetics 32:242-251(1990).
Hunt C.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:6455-6459(1985).
Xie T.,et al.Genome Res. 13:2621-2636(2003).
Shiina S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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