|Other Accession||NM_177551, NP_808219|
|Reactivity||Human, Mouse, Rat, Rabbit, Bovine, Guinea Pig|
|Predicted||Human, Mouse, Rat|
|Alias Symbol||HM74a, HM74b, NIACR1, PUMAG, Puma-g|
|Other Names||Hydroxycarboxylic acid receptor 2, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, Niacin receptor 1, Nicotinic acid receptor, HCAR2, GPR109A, HCA2, HM74A, NIACR1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-HCAR2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HCAR2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR109A, HCA2, HM74A, NIACR1|
|Function||Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.|
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Provided below are standard protocols that you may find useful for product applications.
Wise A.,et al.J. Biol. Chem. 278:9869-9874(2003).
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Kostylina G.,et al.Cell Death Differ. 15:134-142(2008).
Offermanns S.,et al.Pharmacol. Rev. 63:269-290(2011).
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