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HCAR2 antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - HCAR2 antibody - C-terminal region AI15030

    WB Suggested Anti-HCAR2 Antibody Titration: 1.0 μg/ml
    Positive Control: MCF7 Whole Cell
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TDS4
Other Accession NM_177551, NP_808219
Reactivity Human, Mouse, Rat, Rabbit, Bovine, Guinea Pig
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 42kDa
Additional Information
Gene ID 338442
Alias Symbol HM74a, HM74b, NIACR1, PUMAG, Puma-g
Other Names Hydroxycarboxylic acid receptor 2, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, Niacin receptor 1, Nicotinic acid receptor, HCAR2, GPR109A, HCA2, HM74A, NIACR1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-HCAR2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHCAR2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HCAR2
Synonyms GPR109A, HCA2, HM74A, NIACR1
Function Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
Research Areas
Citations (0)

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Wise A.,et al.J. Biol. Chem. 278:9869-9874(2003).
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Kostylina G.,et al.Cell Death Differ. 15:134-142(2008).
Offermanns S.,et al.Pharmacol. Rev. 63:269-290(2011).

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$ 293.00
Cat# AI15030
(40 western blots)
Availability: 2-3 days
Bulk Size
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