|Other Accession||NM_206853, NP_996735|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||DKFZp586I0923, Hqk, QK, QK1, QK3, hqkI|
|Other Names||Protein quaking, Hqk, HqkI, QKI, HKQ|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-QKI antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||QKI antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)- UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients|
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Provided below are standard protocols that you may find useful for product applications.
Li Z.Z.,et al.Jpn. J. Cancer Res. 93:167-177(2002).
Xia J.-H.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Li H.,et al.Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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