|Other Accession||NM_005012, NP_005003|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Guinea Pig, Dog|
|Alias Symbol||MGC99659, NTRKR1, dJ537F10.1|
|Other Names||Tyrosine-protein kinase transmembrane receptor ROR1, 22.214.171.124, Neurotrophic tyrosine kinase, receptor-related 1, ROR1, NTRKR1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ROR1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ROR1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A- mediated signaling.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm|
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Provided below are standard protocols that you may find useful for product applications.
Masiakowski P.,et al.J. Biol. Chem. 267:26181-26190(1992).
Reddy U.R.,et al.Oncogene 13:1555-1559(1996).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Sjoeblom T.,et al.Science 314:268-274(2006).
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