|Other Accession||NM_172168, NP_751908|
|Reactivity||Human, Horse, Bovine|
|Predicted||Human, Horse, Bovine|
|Alias Symbol||MGC20258, P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28|
|Other Names||NADPH oxidase organizer 1, NADPH oxidase regulatory protein, Nox organizer 1, Nox-organizing protein 1, SH3 and PX domain-containing protein 5, NOXO1, P41NOX, SH3PXD5|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-NOXO1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NOXO1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.|
|Cellular Location||Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910)|
|Tissue Location||Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Banfi B.,et al.J. Biol. Chem. 278:3510-3513(2003).
Geiszt M.,et al.J. Biol. Chem. 278:20006-20012(2003).
Takeya R.,et al.J. Biol. Chem. 278:25234-25246(2003).
Cheng G.,et al.J. Biol. Chem. 279:4737-4742(2004).
Cheng G.,et al.Gene 356:118-126(2005).
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