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CERK Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8TCT0 |
| Other Accession | NM_022766, NP_073603 |
| Reactivity | Human, Rat, Horse, Dog |
| Predicted | Human, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59kDa |
| Gene ID | 64781 |
|---|---|
| Alias Symbol | LK4, dA59H18.2, dA59H18.3, hCERK |
| Other Names | Ceramide kinase, hCERK, 2.7.1.138, Acylsphingosine kinase, Lipid kinase 4, LK4, CERK, KIAA1646 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-CERK antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CERK Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CERK |
|---|---|
| Synonyms | KIAA1646 |
| Function | Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2- ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031). |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein |
| Tissue Location | High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Sugiura M.,et al.J. Biol. Chem. 277:23294-23300(2002).
Van Veldhoven P.P.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).
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