|Other Accession||NM_022766, NP_073603|
|Reactivity||Human, Rat, Horse, Dog|
|Predicted||Human, Horse, Dog|
|Alias Symbol||LK4, dA59H18.2, dA59H18.3, hCERK|
|Other Names||Ceramide kinase, hCERK, 22.214.171.124, Acylsphingosine kinase, Lipid kinase 4, LK4, CERK, KIAA1646|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-CERK antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CERK Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung|
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Provided below are standard protocols that you may find useful for product applications.
Sugiura M.,et al.J. Biol. Chem. 277:23294-23300(2002).
Van Veldhoven P.P.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).
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