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> home > Products > Primary Antibodies > Antibody Collections > Mitochondrion > NTHL1 Antibody - N-terminal region
NTHL1 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
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- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P78549 |
| Other Accession | NM_002528, NP_002519 |
| Reactivity | Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34kDa |
| Gene ID | 4913 |
|---|---|
| Alias Symbol | NTH1, OCTS3 |
| Other Names | Endonuclease III-like protein 1 {ECO:0000255|HAMAP-Rule:MF_03183}, hNTH1, 3.2.2.- {ECO:0000255|HAMAP-Rule:MF_03183}, 4.2.99.18 {ECO:0000255|HAMAP-Rule:MF_03183}, Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase {ECO:0000255|HAMAP-Rule:MF_03183}, DNA glycoslyase/AP lyase {ECO:0000255|HAMAP-Rule:MF_03183}, NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183}, NTH1, OCTS3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-NTHL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | NTHL1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183} |
|---|---|
| Synonyms | NTH1, OCTS3 |
| Function | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage (PubMed:9927729, PubMed:29610152). The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta- elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. |
| Cellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:12531031, ECO:0000269|PubMed:9611236}. Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03183, ECO:0000269|PubMed:9611236} |
| Tissue Location | Widely expressed with highest levels in heart and lowest levels in lung and liver. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Aspinwall R.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:109-114(1997).
Imai K.,et al.Gene 222:287-295(1998).
Martin J.,et al.Nature 432:988-994(2004).
Ikeda S.,et al.J. Biol. Chem. 273:21585-21593(1998).
Hilbert T.P.,et al.J. Biol. Chem. 272:6733-6740(1997).
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$ 389.00
Cat# AI15081
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