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>   home   >   Products   >   Primary Antibodies   >   NTHL1 Antibody - N-terminal region   

NTHL1 Antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - NTHL1 Antibody - N-terminal region AI15081

    WB Suggested Anti-NTHL1 Antibody Titration: 1.0 μg/ml
    Positive Control: Fetal Lung
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78549
Other Accession NM_002528, NP_002519
Reactivity Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 34kDa
Additional Information
Gene ID 4913
Alias Symbol NTH1, OCTS3
Other Names Endonuclease III-like protein 1 {ECO:0000255|HAMAP-Rule:MF_03183}, hNTH1, 3.2.2.- {ECO:0000255|HAMAP-Rule:MF_03183}, {ECO:0000255|HAMAP-Rule:MF_03183}, Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase {ECO:0000255|HAMAP-Rule:MF_03183}, DNA glycoslyase/AP lyase {ECO:0000255|HAMAP-Rule:MF_03183}, NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183}, NTH1, OCTS3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-NTHL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsNTHL1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183}
Synonyms NTH1, OCTS3
Function Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Cellular Location Nucleus. Mitochondrion.
Tissue Location Widely expressed with highest levels in heart and lowest levels in lung and liver.
Citations (0)

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Aspinwall R.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:109-114(1997).
Imai K.,et al.Gene 222:287-295(1998).
Martin J.,et al.Nature 432:988-994(2004).
Ikeda S.,et al.J. Biol. Chem. 273:21585-21593(1998).
Hilbert T.P.,et al.J. Biol. Chem. 272:6733-6740(1997).

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$ 293.00
Cat# AI15081
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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