|Application ||WB, IF|
|Other Accession||NM_002203, NP_002194|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||BR, CD49B, GPIa, VLA-2, VLAA2, BDPLT9|
|Other Names||Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, ITGA2, CD49B|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ITGA2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ITGA2 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Takada Y.,et al.J. Cell Biol. 109:397-407(1989).
Schmutz J.,et al.Nature 431:268-274(2004).
Zutter M.M.,et al.J. Biol. Chem. 269:463-469(1994).
Bergelson J.M.,et al.J. Virol. 67:6847-6852(1993).
Graham K.L.,et al.J. Virol. 77:9969-9978(2003).
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