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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CDC14A antibody - C-terminal region   

CDC14A antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - CDC14A antibody - C-terminal region AI15092

    WB Suggested Anti-CDC14A Antibody Titration: 1.0 μg/ml
    Positive Control: RPMI-8226 Whole CellCDC14A is strongly supported by BioGPS gene expression data to be expressed in Human RPMI-8226 cells
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9UNH5
Other Accession NM_003672, NP_003663
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 66kDa
Additional Information
Gene ID 8556
Alias Symbol cdc14, hCDC14
Other Names Dual specificity protein phosphatase CDC14A, 3.1.3.16, 3.1.3.48, CDC14 cell division cycle 14 homolog A, CDC14A
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CDC14A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCDC14A antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC14A
Function Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, spindle Cell projection, kinocilium {ECO:0000250|UniProtKB:Q6GQT0} Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity) {ECO:0000250|UniProtKB:Q6GQT0, ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:15263015}
Research Areas
Citations (0)

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References

Li L.,et al.J. Biol. Chem. 272:29403-29406(1997).
Wong A.K.C.,et al.Genomics 59:248-251(1999).
Hao L.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Belyaev A.S.,et al.Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 293.00
Cat# AI15092
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