|Other Accession||NM_006332, NP_006323|
|Reactivity||Human, Mouse, Rat, Pig, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Sheep, Horse, Bovine, Dog|
|Alias Symbol||GILT, IFI-30, IP30, MGC32056|
|Other Names||Gamma-interferon-inducible lysosomal thiol reductase, 1.8.-.-, Gamma-interferon-inducible protein IP-30, Legumaturain, IFI30, GILT, IP30|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-IFI30 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||IFI30 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).|
|Cellular Location||Secreted. Lysosome.|
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Provided below are standard protocols that you may find useful for product applications.
Luster A.D.,et al.J. Biol. Chem. 263:12036-12043(1988).
Arunachalam B.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:745-750(2000).
Arahira M.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
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